Challenges in RNA Structural Modeling and Design
نویسندگان
چکیده
منابع مشابه
Challenges in RNA Structural Modeling and Design.
Over the past several decades, it has become increasingly clear that functionally active RNA molecules are not restricted to a few unusual examples that are involved in translation (such as transfer RNA and ribosomal RNA) and RNA processing (like spliceosomal RNAs, self-splicing ribozymes, selfcleaving ribozymes and ribonuclease P). Rather, large and small regulatory RNAs are transcribed in abu...
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RNA’s rising stardom is well-justified by its structural variability and functional versatility. Indeed, besides RNA’s key role in the translational machinery, RNA is instrumental for the manipulation and regulation of genetic information. Because regulatory errors and altered RNA functions can trigger abnormal cellular events, RNA has also emerged as a strong drug target for treating a variety...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2016
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2016.02.012